Trying to win the approval of her friends, 17-year-old Tiffany sneaks out of the house to go to a Halloween bash at a fraternity. The fun soon ends when police and the cranky, fast-talking Madea (Tyler Perry) arrive to crash the party. Unhappy with this sudden turn of events, the vengeful collegians decide to scare Madea and her cronies with a series of pranks. She soon finds herself under attack and on the run from an assortment of ghosts, ghouls and zombies on the scariest night of the year.