Several Pookies (the pink bear) were kept on set, but luckily only one had the misfortune of getting tossed in the motel pool.
Padma Lakshmi’s cameo appearance came together right before it was shot, and the scene was written only the night before.
It may look warm, but the scene with Hank, Divya, and Padma was shot in 40 degree weather.
The character Martin, the eldest of the four children that Divya treats, is actually the son of one of Royal Pains’ producers.
Emma’s motel, Harbor Mist, is same location used for the DJ radio party in season 5.
The bicycle shop scene with Evan, Paige, Eddie, and Emma was shot twice – first in Puerto Rico, and then re-shot in New York.
All of the exterior scenes with Annie (Diane Farr) were filmed in Puerto Rico.